One (1) soft chew per 40 lbs of body weight daily. Allow four to six weeks for best results. Individual results may vary. Glucosamine and Chondroitin can cause dogs to have nausea, and sometimes vomiting, if not administered correctly. Follow the label instructions and dosing for best results. Be sure this supplement is given during or after your pet’s meal to reduce incidences of gastrointestinal upset.